大剂量纳洛酮联合灯盏花素治疗急性脑梗死的临床观察

目的 探讨大剂量纳洛酮联合灯盏花素注射液治疗急性脑梗死的临床疗效.方法 选择确诊的急性脑梗死患者80例,随机分为2组.治疗组40例,给予纳洛酮4.0 mg加灯盏花素注射液20 mg,对照组40例,给予纳洛酮1.2 mg加灯盏花素注射液20 mg静脉点滴,每日1次,连用14 d,观察临床疗效、神经功能缺损评分、血液流变情况及不良反应.结果 在神经功能缺损评分及血液流变学改变方面治疗组优于对照组（P＜0.05）.两组在总临床疗效及不良反应方面比较无统计学意义（P＞0.05）.结论 大剂量纳洛酮加灯盏花素注射液治疗急性脑梗死效果显著.

Cinical observation of large dose naloxone plus dengzhanghua injection on treatment of acute cerebral infarction

Objective To observe the therapeutic effect of large dose naloxone plus Dengzhanghua injection on acute cerebral infarction. Methods A total of 80 patients with acute cerebral infarction comfirmed by brain CT were divided into two groups randomly. 40 cases of treatment group was treated with nalosone 4. 0 mg plus Dengzhanghua injection 20 mg in saline solution, while 40 cases of control group was treated with nalosonel. 2 mg plus Dengzhanghua injection 20 mg in saline solution. After 14 days,the therapeutic effects were observed and compar,-：l and complications were recorded. Results The neurologic impairment scoring and hemodynamic indexes were improved obviously in treatment group than controlgroup（ P 〈 0. 05）.There were no statistical difference in total effective rate and complications between two groups（ P 〉 0.05 ）. Conclusion It provided that large dose of naloxone plus Dengzhanghua injection was effective on acute cerebral infarction.