三种方法联合治疗白癜风疗效观察

目的观察复方卡力孜然酊、窄谱中波紫外线（NB—UVB）联合斯奇康治疗白癜风的临床疗效及安全性。方法将人选的196例白癜风患者按就诊时间顺序随机分为4组：A组49例，外用复方矗力孜然酊；B组49例，给予外用复方卡力孜然酊和NB—UVB治疗；C组49例，予复方卡力孜然酊联合斯奇康治疗；D组49例，给予复方卡力孜然酊、NB—UVB与斯奇康联合治疗。4组患者疗程均为12周，疗程结束，比较4组患者的疗效。结果196例中184例完成试验，疗程结束时D组的有效率为77．3％，明显高于A组（37．5％）、B组（68．9％）和C组（617％），差异有显著性意义（P均〈0．05），B组（68．9％）和C组（61．7％）也明显高于A组（37．5％），有统计学意义（P均〈0．05）。B、C两组有效率差异无统计学意义（P〉0．05）。结论复方矗力孜然酊、窄谱中波紫外线（NB—UVB）与斯奇康联合应用治疗白癜风，产生协同效应，安全性好，不良反应少，值得临床推广。

Clinical observation the treatment of kaliziran tincture combined with narrowband ultraviolet B phototherapy and BCG - PSN in the vitiligo

Objective To observe the efficacy and safety of Kaliziran Tincture Combined with Narrowband Ultraviolet B Phototherapy and BCG - PSN in the treatment of vitiligo. Methods 196 patients with vitiligo were divided into four groups randomly. The patients of group A were treated by kaliziran tincture, Group B was treated with Kaliziran Tincture （as Group A） and Ultraviolet B Phototherapy, The patients of group C was treated with Kaliziran Tincture （as Group A） and BCG - PSN, Group D was treated with Kaliziran Tincture Combined with Narrowband Ultraviolet B Photntherapy and BCG - PSN, The four groups all received three months course of treatment. Results 184 patients had finished the treatment and follow - up. After being treated for three months, The difference of the total effective rates among the four groups. The effective rate of group D was 77.3%, significantly higher than group A （37.5%） and B group （68. 9% ） and C（61.7% ）, the difference was significant （ P all 〈 0.05 ） ; B groups （68.9%） and C group （61.7 % ） was significantly higher than A group （ 37.5 % ） were statistically significant P 〈 0.05. However, the efficiency of B, C groups showed no significant difference （P 〉 0.05）. Conclusion Treatment of vitiligo with the kaliziran tincture, NV - UVB and BCG - PSN to produce synerglstie effects, good safety, low side effects, and which should be popularized.