表皮生长因子受体、Ki-67在外阴营养不良组织中的表达

目的 探讨表皮生长因子受体（EGFR）、增殖细胞核抗原Ki-67 在外阴营养不良组织中的表达及其临床意义。方法 免疫组化法对160例外阴营养不良患者皮损中的EGFR、Ki-67表达进行检测，比较EGFR、Ki-67在外阴营养不良各病理类型中表达的差异，并分析其与临床病理特征的相关性。结果 EGFR、Ki-67在外阴营养不良鳞状细胞增生型、硬化苔藓型、混合型中的表达差异无统计学意义（P ＞ 0.05）；EGFR与Ki-67的表达呈正相关，r = 0.66，P ＜ 0.05；EGFR、Ki-67的阳性表达率在不同发病年龄组差异无统计学意义（P > 0.05），在不同病程组差异有统计学意义（P ＜ 0.05）。结论 EGFR、Ki-67阳性表达率在不同病程组有差异。

Expressions of epidermal growth factor receptor (EGFR) and Ki-67 in vulvar dystrophy

Objective To explore the expressions of EGFR and Ki-67 in vulvar dystrophy and their clinical significance Methods Tissue specimens were collected from 160 patients with vulvar dystrophy.Immunohistochemical method was used to detect the expressions of EGFR and Ki-67 in these specimens.The expression levels of EGFR and Ki-67 were compared among different pathological subtypes of vulvar dystrophy,and the relationship of these expressions with clinical pathological characteristics was assessed.Results No significant differences were observed in the expressions of EGFR or Ki-67 between vulvar dystrophy of squamous cell hyperplasia type,lichen sclerosus type and mixed type (P ＞ 0.05).The expression level of EGFR was positively correlated with that of Ki-67 in vulvar dystrophy (r =0.66,P ＜ 0.05).There was a significant difference in the expression rate of EGFR and Ki-67 between patients with different courses of vulvar dystrophy (both P ＜0.05),but not between patients with different age at onset of vulvar dystrophy (both P ＞ 0.05).Conclusion The expressions of EGFR and Ki-67 are different among patients with different courses of vulvar dystrophy.