儿童获得性梅毒14例分析

目的 分析儿童获得性梅毒的临床表现及其治疗方法。方法 回顾分析2007年7月至2010年12月诊治的14例儿童获得性梅毒患者的临床资料。结果 14例患者中10例为二期梅毒，早、晚期潜伏梅毒各2例。14例患者均有与现症梅毒患者密切接触史或被成人梅毒患者口内咀嚼食物后喂养史。所有患者血清快速血浆反应素环状卡片试验（RPR）及梅毒螺旋体血凝试验（TPHA）均阳性。其皮损主要发生于口腔黏膜，躯干少见，表现为黏膜白斑和黏膜湿丘疹、皮肤脓疱等。7例患者被误诊为其他皮肤病。结论 儿童获得性梅毒临床常被误诊或忽视。有不典型皮疹、尤其是与活动性梅毒患者有密切接触者，应考虑儿童获得梅毒可能。

Acquired syphilis in children: 14 case reports

Objective To analyze the clinical manifestations and treatment of acquired syphilis in children.Methods A retrospective analysis was conducted.The clinical data on 14 patients with acquired syphilis collected from July 2007 to December 2010 were assessed.Results Among the 14 cases,10 were secondary syphilis,2 early latent syphilis,and 2 late latent syphilis.Seven of the patients had been misdiagnosed as other diseases.All the patients had a history of close contact with syphilis patients or having mouth-to-mouth feeding history after chewing food by adult patients with syphilis.Both rapid plasma reagin (RPR) test and Treponema pallidum haemagglutination assay (TPHA) were positive in all the patients.The skin lesions were mainly located in the oral cavity mucosa and rarely in the trunk,which included leukoplakia,mucosal wet papules,and pustules.Conclusions Acquired syphilis in children is often clinically misdiagnosed or ignored.For children presenting with atypical skin rashes,especially for those having close contact with active syphilis patients,acquired syphilis should be suspected.