Sugary beverage intake and preclinical Alzheimer's disease in the community |
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| Authors: | Matthew P. Pase Jayandra J. Himali Paul F. Jacques Charles DeCarli Claudia L. Satizabal Hugo Aparicio Ramachandran S. Vasan Alexa S. Beiser Sudha Seshadri |
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| Affiliation: | 1. Department of Neurology, Boston University School of Medicine, Boston, MA, USA;2. Framingham Heart Study, Framingham, MA, USA;3. Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, Australia;4. Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA;5. Jean Mayer-U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA;6. Department of Neurology, School of Medicine & Imaging of Dementia and Aging Laboratory, Center for Neuroscience, University of California Davis, Sacramento, CA, USA;7. Sections of Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, Boston, MA, USA;8. Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA |
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| Abstract: | IntroductionExcess sugar consumption has been linked with Alzheimer's disease (AD) pathology in animal models.MethodsWe examined the cross-sectional association of sugary beverage consumption with neuropsychological (N = 4276) and magnetic resonance imaging (N = 3846) markers of preclinical Alzheimer's disease and vascular brain injury (VBI) in the community-based Framingham Heart Study. Intake of sugary beverages was estimated using a food frequency questionnaire.ResultsRelative to consuming less than one sugary beverage per day, higher intake of sugary beverages was associated with lower total brain volume (1–2/day, β ± standard error [SE] = ?0.55 ± 0.14 mean percent difference, P = .0002; >2/day, β ± SE = ?0.68 ± 0.18, P < .0001), and poorer performance on tests of episodic memory (all P < .01). Daily fruit juice intake was associated with lower total brain volume, hippocampal volume, and poorer episodic memory (all P < .05). Sugary beverage intake was not associated with VBI in a consistent manner across outcomes.DiscussionHigher intake of sugary beverages was associated cross-sectionally with markers of preclinical AD. |
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| Keywords: | Sugar Diet Dementia Alzheimer's disease Framingham Heart Study |
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