Failure to detect association between polymorphisms of the sodium channel gene SCN1A and febrile seizures in Chinese patients with epilepsy |
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| Authors: | Chunbo Zhang Virgina Wong Ping Wing Ng Colin Hiu Tung Lui Ngai Chuen Sin Ka Sing Wong Larry Baum Patrick Kwan |
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| Affiliation: | 1. School of Pharmacy, The Chinese University of Hong Kong, Hong Kong, China;2. Department of Paediatric and Adolescent Medicine, University of Hong Kong, Hong Kong, China;3. Division of Neurology, Department of Medicine and Geriatrics, United Christian Hospital, Hong Kong, China;4. Department of Medicine, Tseung Kwan O Hospital, Hong Kong, China;5. Hospital Authority Head Office, Hong Kong, China;6. Division of Neurology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China |
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| Abstract: | A recent study in Caucasians found an association between the single nucleotide polymorphism (SNP) of SCN1A, IVS5N +5 G>A (rs3812718), and febrile seizures (FS). We examined whether this and other tagging SNPs of SCN1A were associated with an increased risk of FS in Han Chinese. A total of 728 Han Chinese patients with focal epilepsy were recruited: 97 had a history of FS (58% male, mean age 35 ± 12 years) and 631 did not (50% male, mean age 40 ± 15 years). Genotyping was performed for IVS5N +5 G>A and seven other tagging SNPs selected from the HapMap database. Genotyping was also performed in 848 ethnically matched population controls (50% male, mean age 37 ± 17 years). There was no statistically significant difference in either allele or genotype frequency of any of the SNPs studied between epilepsy patients with and without FS, and between epilepsy patients with FS and controls. The results do not suggest that SCN1A SNPs are susceptibility factors for FS in Han Chinese. |
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| Keywords: | Febrile seizures SCN1A Epilepsy Chinese |
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