Absence of initiating activity by quercetin in the rat liver |
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| Authors: | K Kato H Mori T Tanaka M Fujii T Kawai A Nishikawa M Takahashi I Hirono |
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| Affiliation: | 1. Department of Pathology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu, 500 Japan;2. Department of Pathology, Jichi Medical School, Kawachi-gun, Tochigi, 329-04 Japan;3. Department of Pathology, Fujita-Gakuen University School of Medicine, Toyoake City, Aichi, 470-11, Japan |
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| Abstract: | Initiating activity of quercetin was tested in rats which were treated with partial hepatectomy and given a liver cancer promoter, phenobarbital. A few intestinal neoplasms were seen but without significant difference in incidence from those in the quercetin-untreated group. Moreover, neither neoplastic nor preneoplastic liver changes were detected in quercetin-treated groups. With hepatocyte primary culture/DNA repair test, quercetin did not produce genotoxicity. The results show that quercetin has no initiating or genotoxic activities in the rat liver. |
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| Keywords: | To whom requests for reprints should be addressed. |
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