Chemical constituents from the Colombian medicinal plant Maytenus laevis |
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| Authors: | Nakagawa Hiroyuki Takaishi Yoshihisa Fujimoto Yoshinori Duque Carmenza Garzon Cristina Sato Mitsunobu Okamoto Masato Oshikawa Tetsuya Ahmed Sharif Uddin |
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| Affiliation: | Faculty of Pharmaceutical Sciences, University of Tokushima, Sho-machi, Tokushima 770-8505, Japan. |
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| Abstract: | The methanol extract of the bark of the Colombian medicinal plant Maytenus laevis gave six new compounds and 28 known compounds. The structures of the new and known compounds were elucidated on the basis of spectroscopic evidence. Several of these compounds were screened for cytokine-inducing activity on human PBMCs to investigate antitumor effects, and canophyllol (12) demonstrated the most effective induction of the cytokines. |
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