血栓性疾病患者血浆可溶性细胞间粘附分子1水平与微血栓形成

目的为进一步探讨血栓性疾病患者血流中微血栓形成的发生机理。方法采用酶联免疫吸附（ＥＬＩＳＡ）法，检测４３例血栓性疾病（脑血栓１９例，肺栓塞１７例，下肢静脉血栓７例）患者血浆可溶性细胞间粘附分子１（ｓＩＣＡＭ－１）水平。结果血栓性疾病患者血浆ｓＩＣＡＭ－１水平明显高于正常健康组（白色微小血栓形成组Ｐ<０．０１，单纯红细胞聚集组Ｐ＜０．０５），尤以白色微小血栓形成组最为显著。结论血栓性疾病患者血浆ｓＩＣＡＭ－１水平与微血栓形成密切相关，因此检测血浆ｓＩＣＡＭ－１水平，对血栓性疾病的早期诊断、疾病预防和药物疗效观察有意义，是一个重要标志物。

The Level of Soluble Intercellular Adhesion Molecules 1 and Microthrombosis in Plasm of Patients with Thrombosed Disease

Objective To explore the occurring mechanism of microthrombosis in blood of patients with thrombosed disease.Methods To examine the level of soluble intercellular adhesion molecules 1 (sICAM-1) in plasm of 43 patients with thrombosed disease by enzyme linked- immunosorbent assay (Cerebral thrombosis 19 cases, Pulmonary embolism 17 cases, Vein thrombosis in legs 7 cases). Results The level of sICAM-1 in plasm of patients with thrombosed disease is evidently higher than that in normal control group (White microthrombosis group P<0.01;Simple erythrocyte collecting group P<0.05),it has most significant difference in white microthrombosis group.Conclusion The level of sICAM-1 in plasm of patients with thrombosed disease is closely related to the formation of microthrombosis, to examine the level of sICAM-1 in plasm is significant in early diagnosis .disease prevention and observation of therapeutic effects,sICAM-1 is an important marker.