Brain dopamine receptor levels elevated in canine narcolepsy |
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| Authors: | S S Bowersox T S Kilduff K F Faull L Zeller-DeAmicis W C Dement R D Ciaranello |
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| Affiliation: | 1. Department of Neurobiology, The Fourth Military Medical University, Xi''an 710032, PR China;2. Department of Pathology and Pathophysiology, The Fourth Military Medical University, Xi''an 710032, PR China;3. School of Biomedical Sciences, The University of Hong Kong, PR China;4. Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA |
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| Abstract: | Concentrations of dopamine D2 receptors in discrete brain areas differed significantly between dogs with the genetically transmitted form of narcolepsy, and age- and breed-matched controls. D2 receptors were assayed and quantified with Scatchard analysis using [3H]spiperone. Receptor densities in the nucleus accumbens, rostral caudate, and amygdala were consistently higher in narcoleptic animals. In amygdala, dopamine receptor abnormalities were associated with elevated dopamine and 3,4-dihydroxyphenylacetic acid concentrations, but no change in 3-methoxytyramine or homovanillic acid concentrations. These data indicate mesolimbic system involvement in canine narcolepsy and point to impaired dopamine release as a possible etiologic factor. |
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