Synthesis and antiproliferative activity in vitro of new 3-substituted aminopyrazolo[3,4-b]pyridines |
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Authors: | Poreba Krystyna Opolski Adam Wietrzyk Joanna |
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Institution: | Department of Technology of Drugs, Wroc?aw University of Medicine, Poland. krysia@bf.uni.wroc.pl |
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Abstract: | The synthesis of several new 3-substituted aminopyrazolo3,4-b]pyridines is described. The obtained compounds were tested for their antiproliferative activity in vitro. Two of them: 3-chloroacetylaminopyrazolo3,4-b]pyridine II] and 3-(2-bromopropionyl-amino)pyrazolo3.4-b]pyridine III] revealed cytotoxic activity against the cells of 5 human tumor cell lines applied. Their ID50 values were in the range of the international activity criterion for synthetic agents (4 microg/ml). The structures of the products II-XVII were established on the basis of elemental analysis and spectral data (IR, 1H NMR and MS). |
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