Gene assignment of α-fucosidase and glucose dehydrogenase to the p21→pter region of chromosome 1 in man |
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Authors: | G. A. Koch J. A. Brown T. B. Shows |
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Affiliation: | (1) Biochemical Genetics Section, New York State Department of Health, Roswell Park Memorial Institute, 14263 Buffalo, New York;(2) Department of Human Genetics, Medical College of Virginia, 23298 Richmond, Virginia |
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Abstract: | Assignment of human genes coding for -fucosidase ( FUC) and glucose dehydrogenase (GDH) to chromosome 1 has been confirmed and a location in the p21 pter region demonstrated using man-mouse somatic cell hybrids. The regional location af FUC andGDH was established in cell hybrids using human cells possessing 1/2 translocation chromosomes [46,XX,t(1;2)(p21;q37)]. Hybrids which retained the 2q+ chromosome carrying the 1p21 1pter region concordantly expressed FUC, GDH, and the short-arm markers ENO1, AK2, and PGM1. Hybrids which retained the 1p21 1qter region only expressed human PEPC and FH. Data obtained from hybrids in which spontaneous breaks in chromosome 1 had occurred indicate that the gene order in 1p21ar1pter is (ENO1,GDH)- FUC-AK2-PGM1. |
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