肝硬化患者血小板参数及凝血指标检测的临床意义

目的探讨肝硬化患者血小板参数及凝血指标检测的临床意义。方法对45例肝硬化患者的血小板数（PLT）、血小板压积（PCT）、血小板平均体积（MPV）、血小板分布宽度（PDW）和凝血酶原时间（PT）、活化的部分凝血酶时间（APTT）、国际标准化比值（INR）、纤维蛋白原（FIB）与40例健康对照组进行比较。结果与健康对照组比较，肝硬化患者的PLT、PCT显著降低（P〈0．05），MPV、PDW显著升高（P〈0．05），PT、APTT、INR明显延长（P〈O．05），FIB明显减少（P〈0．01）。结论肝硬化患者的血液处于明显的低凝状态，血小板参数及凝血相关指标检测对了解肝硬化患者肝功能损害程度、判断有无出血倾向、指导临床治疗及判断预后都有重要意义。

THE CLINICAL SIGNIFICANCE OF DETECTING PLATELET PARAMETERS AND COAGULATION INDEXES IN PATIENTS WITH LIVER CIRRHOSIS

Objective To explore the clinical significance of detecting platelet parameters and coagulation indexes in patients with liver cirrhosis. Methods The number of platelet（PLT）, the plateletcrit （PCT）, the mean platelet volume （MPV）, the platelet distribution width （PDW）, the prothrombin time （PT）, the activated partial thromboplastin time （APTT） ,the international normalized ratio （INR） and the humber of fibrinogen （FIB） in 45 cases of liver cirrhosis were compared with 40 healthy cases. Results Compared with those in the healthy group, the PLT and PCT were obviously lower in the group of liver cir- rhosis （ P 〈0.05）, the MPV and PDW were obviously higher （ P 〈0.01）, the PT, APTT and INR were significantly prolonged （ P 〈0.05）, and the FIB was significantly reduced （ P 〈0.01）. Conclusion The blood of patients with liver cirrhosis were obviously in low coagulation state and the detection of platelet parameters and the blood-related coagulation indexes are important for understanding the extent of Liver damage, judging the tendency of bleeding, guiding clinical treatment and judging prognosis.