IN VIVO COMPARATIVE OBSERVATION ON THE INVASIVENESS OF VARIOUS ORGANS BY DIFFERENT LEUKEMIA CELLS

Using patho-morphological method and transplantation bio-assay, the in vivo invasiveness of leukemia cells is three transplantable mouse T cell leukemia models was comparatively studied. The results showed that the invasion to the liver was consistent, but that to other organs was obviously different. L615 and L7212 leukemia cells preferred to the bone marrow and spleen than to the peritoneum while L7811 leukemia cells were just the opposite. Transplantation bio-assay demonstrated that leukemia cells were present in the bone marrow of L615 mice as early as 6 hours after leukemic cell inoculation, but no leukemia cells was detected in bone marrow of L7811 mice 2 days after inoculation. In the terminal phase, L615 mice bone marrow became filled with leukemia cells, but L7811 mice bone marrow contained only a few leukemia cells. The difference of invasiveness of leukemia cells among organs is probably related to "homing" receptor. The same type of leukemia cells may possess multiple "homing" receptor.

In vivo comparative observation on the invasiveness of various organs by different leukemia cells

Using patho-morphological method and transplantation bio-assay, thein vivo invasiveness of leukemia cells is three transplantable mouse T cell leukemia models was comparatively studied. The results showed that the invasion to the liver was consistent, but that to other organs was obviously different. L₆₁₅ and L₇₂₁₂ leukemia cells preferred to the bone marrow and spleen than to the peritoneum while L₇₈₁₁ leukemia cells were just the opposite. Transplantation bio-assay demonstrated that leukemia cells were present in the bone marrow of L₆₁₅ mice as early as 6 hours after leukemic cell inoculation, but no leukemia cells was detected in bone marrow of L₇₈₁₁ mice 2 days after inoculation. In the terminal phase, L₆₁₅ mice bone marrow became filled with leukemia cells, but L₇₈₁₁ mice bone marrow contained only a few leukemia cells. The difference of invasiveness of leukemia cells among organs is probably related to “homing” receptor. The same type of leukemia cells may possess multiple “homing” receptor.