| 小鼠原位肝移植模型的建立 |
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| 引用本文： | 万赤丹,刘涛,周峰,熊炯忻,许逸卿,王春友. 小鼠原位肝移植模型的建立[J]. 华中科技大学学报(医学版), 2004, 33(3): 357-359 |
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| 作者姓名： | 万赤丹 刘涛 周峰 熊炯忻 许逸卿 王春友 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院普外科,武汉,430022 |
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| 摘 要： | 目的 建立小鼠原位肝移植模型 ,探讨建模中的手术技巧。方法 采用同系C5 7BL雄性小鼠 ,双袖套法建立小鼠原位肝移植模型 ,共完成 4 0例。结果 手术成功率达到 85 % ,受体长期存活率 (>10 0d)约为 70 % ,移植肝功能保持良好。结论 该模型制作手术成功率高 ,是一种理想的肝移植实验研究模型。
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| 关 键 词： | 肝移植 小鼠 模型 |
| 修稿时间： | 2003-12-10 |
Surgical Experience of Orthotopic Liver Transplantation Model in Mice |
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| Wan Chidan,Liu Tao,Zhou Feng et al. Surgical Experience of Orthotopic Liver Transplantation Model in Mice[J]. Journal of Huazhong University of Science and Technology(Health Sciences), 2004, 33(3): 357-359 |
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| Authors: | Wan Chidan Liu Tao Zhou Feng et al |
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| Affiliation: | Wan Chidan,Liu Tao,Zhou Feng et al Department of Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022 |
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| Abstract: | Objective To establish orthotopic liver transplantation model in mice and explore related surgical skills. Methods C57BL lean mice served as liver donors and recipients. Forty cases of orthotopic liver transplantation (OLT) in mice were carried out using a two-cuff techinique at infrahepatic cava and portal vein. Results 85 % operating successful rate was achieved. The long-term survival rate of the recipients was 70 % (>100 days) and liver graft function was satisfactory. Conclusion OLT in mice was an ideal model for experimental research of live transplantation. |
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| Keywords: | liver transplantation mice model |
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