| 阿奇霉素片的人体药物动力学及相对生物利用度 |
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| 引用本文： | 石晶,宋洪杰,李珍,范国荣,楼国庭. 阿奇霉素片的人体药物动力学及相对生物利用度[J]. 中国医药工业杂志, 2001, 32(5): 215-217 |
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| 作者姓名： | 石晶 宋洪杰 李珍 范国荣 楼国庭 |
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| 作者单位： | 1. 第二军医大学长海医院临床药理室,
2. 上海医药工业研究院, |
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| 摘 要： | 研究了20名健康志愿者单剂量口服两种阿奇霉素片后的血药浓度经时过程，以及两者的生物等效性评价。以微生物法测定血清中阿奇霉素的浓度，供试制剂的Cmax为580.75±156.62μg/L，T
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| 关 键 词： | 阿奇霉素 药物动力学 生物利用度 微生物法 大环内酯类 |
| 文章编号： | 1001-8255(2001)05-0215-03 |
| 修稿时间： | 2001-02-06 |
Pharmacokinetics andRelative Bioavailability of Azithromycin Tablets |
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| SHI Jing,SONG Hong-Jie,LI Zhen,FAN Guo-rong,LOU Guo-Ting. Pharmacokinetics andRelative Bioavailability of Azithromycin Tablets[J]. , 2001, 32(5): 215-217 |
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| Authors: | SHI Jing SONG Hong-Jie LI Zhen FAN Guo-rong LOU Guo-Ting |
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| Affiliation: | SHI Jing 1,SONG Hong Jie 1,LI Zhen 1,FAN Guo Rong 1,LOU Guo Ting 2 |
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| Abstract: | The concentration-time process of azithromycin tablets in 20 healthy volunteers was observed.The plasma concentrations of azithromycin were determined by microbiological method.The pharmacokinetic parameters for the single oral dose of tested tablets were Cmax 580.75±156.62 μg/L,Tmax 1.60±0.68 h，t1/2 36.60±3.74 h，MRT 40.30±5.43 h and AUC0→144 4491.03±979.05 μg*h*L-1.The main pharmacokinetic parameters were not significantly different between the tested and reference tablets,except Tmax (2.45±0.69 h for the latter).The relative bioavalability of tested tablets was 97.14±11.28%. |
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| Keywords: | azithromycin pharmacokinetics bioavailability microbiologic assay |
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