Systemic lupus erythematosus and human endogenous retroviruses |
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| Authors: | Iwao Sekigawa Hitoshi Ogasawara Toshio Naito Hiroshi Kaneko Takashi Hishikawa Hiroshi Hashimoto |
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| Affiliation: | (1) Department of Medicine, Juntendo University Izu-Nagaoka Hospital, 1129 Nagaoka, Izu-Nagaoka-cho, Tagata-gun, Shizuoka 410-2295, Japan Tel. +81-5-5948-3111; Fax +81-5-5948-5088 e-mail: sekigawa@mtd.bioglobe.ne.jp, JP;(2) Department of General Medicine, Juntendo University School of Medicine, Tokyo, Japan, JP;(3) Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, JP |
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| Abstract: | Human endogenous retroviruses (HERV) are known to be widely present in the human genome. Several investigations have suggested a possible etiological role of HERV in certain human disorders, including systemic lupus erythematosus (SLE). Here we review and discuss the possible role of HERV, especially HERV clone 4-1, in the onset of SLE, based on recent findings including our own data. Received: September 25, 2002 / Accepted: December 10, 2002 |
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| Keywords: | DNA methylation Human endogenous retrovirus (HERV) Interleukin (IL)-16 Systemic lupus erythematosus (SLE) |
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