| 江西地区汉族人群4个STR基因座的遗传多态性 |
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| 引用本文： | 肖莉,孙瑜,李国良,刘强.江西地区汉族人群4个STR基因座的遗传多态性[J].江西医学检验,2014(3):249-251. |
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| 作者姓名： | 肖莉 孙瑜 李国良 刘强 |
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| 作者单位： | 江西省血液中心血源管理科,江西南昌330077 |
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| 摘 要： | 目的：调查分析江西地区汉族人群无关个体 D18S51和D12S391、D19S433和D21S114个基因座的遗传多态性。方法采集江西地区汉族无关个体ACD抗凝全血，应用PCR-STR检测D18S51和D12S391、D19S433和D21S11四个STR基因座的等位基因。结果 D18S51、D12S391、D19S433和D21S11的基因座杂合度（H）分别为0.8693、0.8476、0.8123和0.823；个人识别率（DP）分别为0.9685、0.9559、0.9395和0.9459；非父排除率（PE）分别为0.7373、0.6944、0.6354和0.654；多态信息含量（PIC）分别为0.8541、0.8279、0.7869和0.7996。结论本次调查4个STR位点在江西地区汉族人群的分布符合Hardy-Weinberg平衡，遗传多态性高。本次调查为法医学个人识别和亲权鉴定提供遗传学数据。
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| 关 键 词： | 短串联重复序列（STR） 聚合酶链反应（PCR） 遗传多态性 |
Genetic polymorphisms of four STR loci in Han nationality population in Jiangxi province |
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| Institution: | XIAO Li, SUN Yu, LI Guoliang, et al.(Jiangxi Blood Center, Nanchang 330077,China) |
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| Abstract: | Objective To survey and analyze the genetic polymorphisms distribution of 4 STR loci in Han population of Jiangxi. Methods The ACD-samples in Han population of Jiangxi were collected, PCR-STR multiplexing amplification and DNA-PAGE were used to detect the 4 STR loci. Results The heterozygosity of D18S51, D12S391, D19S433 and D21S11 was 0.8693, 0.8476, 0.8123 and 0.823, respectively. Their discriminating power was 0.9685, 0.9559, 0.9395 and 0.9459, respectively. Their probability of exclusion was 0.7373、0.6944、0.7869 and 0.7996, respectively. Conclusion The 4 STR loci distribution we investi-gated accord with Hardy-Weinberg＇s balance. The genetic polymorphisms of 4 STR loci in Han population of Jiangxi are high. This survey provides genetic data for forensic personal identification and paternity testing. |
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| Keywords: | Short tandem repeats Polymerase chain reaction Genetic polymorphis |
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