| 川芎嗪眼部电离子导入治疗玻璃体出血的实验研究 |
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| 引用本文： | 王燕,薛淑红,余杨桂,沈兰芳,李志英,柯雪红.川芎嗪眼部电离子导入治疗玻璃体出血的实验研究[J].眼科,2004,13(1):41-44. |
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| 作者姓名： | 王燕 薛淑红 余杨桂 沈兰芳 李志英 柯雪红 |
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| 作者单位： | 1. 广州中医药大学第一附属医院眼科,广州,510405
2. 广州中医药大学第一附属医院实验中心 |
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| 基金项目： | 广东省教育厅自然科学研究项目 (2 0 0 0 74 ) |
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| 摘 要： | 目的：探讨川芎嗪注射液电离子导入治疗玻璃体出血的疗效及机理。方法：将兔实验性玻璃体出血模型18只(36只眼)随机分为对照组和用药组2组，对照组：不做任何治疗，观察出血的自然转归；用药组：予盐酸川芎嗪注射液电导入治疗。分不同时间点抽取兔房水和玻璃体，用高效液相色谱法测定房水和玻璃体中的药物浓度。用检眼镜观察眼底的可见度，以判断玻璃体出血吸收的情况。结果：对兔实验性玻璃体出血，川芎嗪注射液电离子导入组出血吸收较对照组快。结论：盐酸川芎嗪注射液电离子导入法可促进玻璃体出血的吸收，缩短病程，是一种简易有效的眼局部治疗方法。
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| 关 键 词： | 玻璃体出血／治疗 川芎嗪／治疗应用 电离子导入疗法 |
| 文章编号： | 1004-4469(2004)01-0041-04 |
Experimental study on ligustrazine HCl-iontophoresis on vitreous hemorrhage |
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| WANG Yan etal..Experimental study on ligustrazine HCl-iontophoresis on vitreous hemorrhage[J].Ophthalmology in China,2004,13(1):41-44. |
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| Authors: | WANG Yan etal |
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| Abstract: | Objective:To investigate the effect and mechanism of ligustrazine HCl-iontophoresis on vitreous hemorrhage(VH).Methods:The experiment rabbits with VH(36 eyes) were randomly divided into two groups:the 1st group was control group without any medicine;the 2nd group was treated group with ligustrazine HCl-iontophoresis.Aqueous humor and vitreous were withdrawn at different time,and the drug concentration in aqueous humor and vitreous were determined with high-pressure liquid chromatography(HPLC).The absorption of vitreous hemorrhage was detected with ophthalmoscope.Results:In the experimental VH rabbits,the hemorrhage was absorbed quicker than in the control group,showing the effect of ligustrazine HCl-iontophoresis was better than that in control group.Conclusion:For vitreous hemorrhage,ligustrazine HCl-iontophoresis is an effective and simple therapy,which can accelerate the absorption of VH and shorten the course of treatment. |
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| Keywords: | vitreous hemorrhagetherapy ligustrazinetherapeutic use iontophoresis |
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