| 齐墩果酸分散片的制备研究 |
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| 引用本文： | 孙旭群,吴正红,李燕. 齐墩果酸分散片的制备研究[J]. 安徽医药, 2010, 14(9): 1013-1015. DOI: 10.3969/j.issn.1009-6469.2010.09.008 |
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| 作者姓名： | 孙旭群 吴正红 李燕 |
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| 作者单位： | 安徽医科大学第一附属医院药剂科,国家中医药管理局中药三级实验室,安徽,合肥,230022;中国药科大学,江苏,南京,210009 |
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| 基金项目： | 2007年安徽省高等学校省级自然科学研究项目 |
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| 摘 要： | 目的制备齐墩果酸分散片,并与普通片进行体外溶出度比较。方法制备齐墩果酸固体分散体,以分散均匀性为指标,采用单因素考察及正交试验设计对齐墩果酸分散片处方工艺进行优化。结果优化的处方工艺为微晶纤维素与乳糖比例为4：1,交联聚维酮8%,硬度4 kg.mm-2,溶出度明显快于普通片。结论齐墩果酸分散片制备工艺简单,分散均匀性符合要求,溶出速率快。
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| 关 键 词： | 齐墩果酸 固体分散体 分散片 正交设计 溶出度 |
Preparation of oleanolic acid dispersible tablets |
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| SUN Xu-qun,WU Zheng-hong,LI Yan. Preparation of oleanolic acid dispersible tablets[J]. Anhui Medical and Pharmaceutical Journal, 2010, 14(9): 1013-1015. DOI: 10.3969/j.issn.1009-6469.2010.09.008 |
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| Authors: | SUN Xu-qun WU Zheng-hong LI Yan |
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| Affiliation: | 1.Dept of Pharmacy,The First Affiliated Hospital of Anhui Medical University,The Third Grade State TCM TraditionalMedicine Laboratory,Hefei 230022;2.China Pharmaceutical University,Nanjing 210009) |
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| Abstract: | Aim To prepare oleanolic acid dispersible tablet and compare its vitro dissolution with conventional tablets.Methods Oleanolic acid solid dispersion was prepared and formulation and preparation procedure was optimized by monofactorial investigation and orthogonal design.Results The results showed that the most optimized formulation and preparation procedure were as follows： ratio between microcrystalline cellulose and lactose was 4：1,polyvinylpolypyrrolidone 8%,hardness 4 kg·mm-2.The dissolution rate of dispersible tablets was higher than that of conventional tablets.Conclusion The oleanolic acid dispersible tablets had the characteristics of the simple preparation,fast and homogeneously dispersing and fast dissolution speed. |
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| Keywords: | oleanolic acid solid dispersion dispersible tablets orthogonal design dissolution rate |
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