乙型肝炎病毒表面抗原定量检测在慢性 HBV 感染管理中的意义

随着血清乙型肝炎病毒表面抗原（ HBsAg）自动化定量检测技术的发展，HBsAg定量检测在慢性HBV感染管理中的意义越来越受到关注。研究表明，HBsAg定量检测联合HBV DNA水平不仅可以监测慢性HBV感染自然史的不同阶段，而且可以预测干扰素疗效。但是，对于核苷（酸）类药物，HBsAg定量检测在评估抗病毒疗效方面的作用尚不一致。此文综合近年来国内外相关临床研究结果，分析血清HBsAg水平定量检测在慢性HBV感染管理中的作用。

Clinical signification of hepatitis B surface antigen quantification in management of chronic HBV infection

With the development of automated quantitative detection of serum hepatitis B surface antigen （ HBsAg） , HBsAg quantification is becoming increasingly important in management of chronic HBV infections.Studies have shown that HBsAg quantification together with HBV DNA load may be used to monitor the natural history of chronic HBV infection as well as to predict the clinical outcome of interferon treatment.However, there is no consensus on the clinical use of HBsAg quantification for evaluating patients′responses to nucleos（ t） ide analogues therapy.This paper reviews the up-to-date clinical studies on the clinical significance of HBsAg quantification in management of chronic HBV infection.