Epitopes recognized by CBV4 responding T cells: effect of type 1 diabetes and associated HLA-DR-DQ haplotypes |
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Authors: | Marttila Jane Hyöty Heikki Näntö-Salonen Kirsti Simell Olli Ilonen Jorma |
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Affiliation: | JDRF Center for Preevention of Type 1 Diabetes in Finland, Finland. jane.marttila@utu.fi |
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Abstract: | The present study aimed at characterizing the epitopes recognized by coxsackievirus B4 (CBV4)-specific T-cell lines established from 23 children with type 1 diabetes (T1D) and 29 healthy children with T1D risk-associated HLA genotypes. Responsiveness to VP1 region was dependent on the specific infection history as 55% of the T-cell lines from donors with neutralizing antibodies to CBV serotypes responded to VP1 peptides compared to none of the T-cell lines from other donors (P = 0.01). The pattern of recognized peptides was dependent of the HLA genotype. Forty-two percent of the T-cell lines from donors carrying the HLA-(DR4)-DQB1*0302 haplotype responded to VP1 peptides 71-80 compared to none of the T-cell lines from donors without this haplotype (P = 0.02). No evidence for the existence of diabetes-specific epitopes was found. Only few epitopes were exclusive recognized by T cells from diabetic children, and in each case only one or two T-cell lines were responding. |
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Keywords: | Coxsackievirus B4 (CBV4) Enterovirus T-cell epitope Cell-mediated immunity HLA Type 1 diabetes (T1D) |
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