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Direct quantitation of antiseptic quaternary ammonium compounds by fast atom bombardment mass spectrometry |
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| Authors: | Alberti M B Pinzauti S Moneti G Agati G Giannellini V Coran S A Vincieri F F |
| Institution: | a Dipartimento di Scienze Farmaceutiche, Università di Firenze, Via G. Capponi 9, 50121 Firenze, Italy b Centro di Spettrometria di Massa e Analisi Frammentografiche, Facoltà di Medicina e Chirurgia, Università di Firenze, Viale G. B. Morgagni 65, 50134 Firenze, Italy |
| Abstract: | The medicinally important quaternary ammonium salts benzyldimethyltetradecylammonium chloride (BDTA), cetylpyridinium chloride and benzethonium chloride, all afford, under fast atom bombardment (FAB) mass spectrometric conditions, abundant and persistent M---Cl]+ species usefully amenable to quantitative analysis with the aid of thioglycerol as a liquid FAB matrix. The use of BDTA as an internal standard allowed a direct, precise and accurate determination of cetylpyridinium and benzethonium chlorides, either as pure samples or in dosage forms, in the concentration range 0.05–2 mg/ml. |
| Keywords: | FAB mass spectrometry quantitative application quaternary ammonium salts determination pharmaceutical preparations |
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