RVVC和妊娠期RVVC的治疗探讨

目的：探讨复发性外阴、阴道假丝酵母菌病（RVVC）和妊娠期复发性VVE的合理有效治疗方案。方法：选择140例RVVC确诊患者，随机分3组：A组、口服易启康；B组、口服易启康＋克霉唑栓阴道上药；C组、在B组基础上再进行维持治疗。3组均进行6个疗程治疗，治疗完成后第4、8、12、24周进行疗效评定。选择75例妊娠期复发性VVC确诊患者，随机分3组，采用凯妮汀500mg阴道上药。A组3d1次，连续2次；B组3d1次，连续2次为1疗程，共2个疗程；C组为6d1次，连续使用15次，于治疗后7、14、28d进行疗效评定。结果：3组RVVC治疗4周后差异无统计学意义（P〉0．05），治疗8周后A组对于B、C组治愈率差异有统计学意义（P〈0．05），24周后A组对于B、C组复发率差异有统计学意义（P〈0．05）。妊娠期复发性VVC，3组用药7d、14d和28d后治愈率差异有统计学意义（P〈0．05），治疗后14d和28d复发率差异有统计学意义（P〈0．05）。结论：联合用药周期治疗是治疗RVVC最有效可行的方案；凯妮汀栓治疗妊娠期复发性VVC安全有效，使用方便，维持治疗疗效更高。

The Study of Treatment in Recurrent Vulvovaginal Candidiasis and Pregnant Women with Recurrent Vulvovaginal Candidiasis

Objective：To explore a reasonable and effective treatment program of RVVC and pregnant women with RVVC. Methods ：Choose RVVC 140 cases diagnosed patients, all patients were randomly divided into three groups. Group A：Oral Yi Qikang; Group B：not only Yi Qikang but clotrimazole vaginal suppositories;Group C：in Group B on the basis of further maintenance therapy of clotrimazole vaginal suppositories. Three groups repeated treatment for six courses. After the completion of the six courses treatment, all patients carried a clinical evaluation. Choose 75 pregnant women diagnosed RVVC, randomly divided into three groups, treated with Canesten. Group A for twice, group B for two courses,and group C for 15 times use of canesten. Clinical evaluation were compared 7 days, 14days,28 days after treatment. Results ：Three RVVC groups＇ cure rate after treatment for 4 weeks was no significant difference（ P 〉 0.05 ） , and 8 weeks after treatment compared with A B, C cure rate was significant （ P 〈 0.05 ）, after 24 weeks compared with A B, C recurrence rate statistics significance（ P 〈 0.05 ）. There was significant difference in the cure rate among the three groups of pregnant women after the treatment of 7 days （P 〈 0.05 ）, while among the three groups after the treatment of 28 days, there was significant difference in cure rate and relapse rate （P 〈 0.05 ）. Concluslon：Oral Yi Qikang adds the vagina to treat RVVC with the medicine is the most effective and reasonable treatment program. The treatment of 15 times use of Canesten is more effective for pregnant women with RVVC.