| 维生素B1催化合成1-(3-甲氧基-4-丙氧基-5-硝基苯基)-4-(3,4,5-三甲氧基苯基)-1,4-二酮 |
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| 引用本文： | 夏晓明,姚志艺,张奕华.维生素B1催化合成1-(3-甲氧基-4-丙氧基-5-硝基苯基)-4-(3,4,5-三甲氧基苯基)-1,4-二酮[J].中国药物化学杂志,2003,13(3):168-169. |
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| 作者姓名： | 夏晓明 姚志艺 张奕华 |
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| 作者单位： | 中国药科大学新药研究中心,江苏,南京,210009 |
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| 基金项目： | NationalNaturalScienceofFoundation (No 39770 86 9)supportedproject |
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| 摘 要： | 研究以NaCN和维生素B1为催化剂合成MK-287的关键中间体1-(3-甲氧基-4-丙氧基-5-硝基苯基)-4-(3，4，5-三甲氧基苯基)-1，4-二酮（1）的催化效果。结果表明：维生素B1较文献报道的催化剂ETB具有反应时间短、成本低廉的优点，可代替ETB合成目的化合物。
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| 关 键 词： | 药物化学 制备 工艺研究 1－（3－甲氧基－4－丙氧基－5－硝基苯基）－4－（3，4，5－三甲氧基苯基）－1，4－二酮 VB1 催化剂 |
Vitamin B1 catalyzed the synthesis of 1-(3-methoxy-4-propyloxy-5-nitrophenyl)-4-(3,4,5-trimethoxyphenyl)-1,4-diketone |
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| XIA Xiao-ming,YAO Zhi-yi,ZHANG Yi-hua.Vitamin B1 catalyzed the synthesis of 1-(3-methoxy-4-propyloxy-5-nitrophenyl)-4-(3,4,5-trimethoxyphenyl)-1,4-diketone[J].Chinese Journal of Medicinal Chemistry,2003,13(3):168-169. |
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| Authors: | XIA Xiao-ming YAO Zhi-yi ZHANG Yi-hua |
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| Abstract: | In order to find a desirable catalyst for the preparation of 1-(3-methoxy-4-propyloxy-5-nitrophenyl)-4-(3,4,5-trimethoxyphenyl)-1,4-diketone(1),NaCN and VB_1 were tried and their efficiency was compared.It was found that compared with the catalyst,3-benzyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride(ETB)reported in the literature,VB_1 has advantage of shorter reaction time and lower cost and can replace ETB for the synthesis of 1. |
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| Keywords: | medicinal chemistry preparation process research 1-(3-methoxy-4-propyloxy-5-nitrophenyl)-4-(3 4 5-trimethoxyphenyl)-1 4-diketone Vitamin B_1 catalyst |
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