乳腺癌化疗致闭经的利弊及随后的内分泌治疗

化疗致闭经是一个客观过程，影响因素基本明确，而且对激素受体阳性的患者，化疗致闭经可改善无病生存和总生存，所以对一些预后好和希望保留卵巢功能的患者我们可以进行干预尽可能保护卵巢功能；而对一些高危、预后差的患者，如果化疗未致闭经，可以采用进一步卵巢抑制的方法，以达到闭经，从而获得更好的疗效，这是一个客观、容易观察的指标。

Incidence of chemotherapy-induced amenorrhea and further endocrine therapy thinking in breast cancer

Chemotherapy-induced amenorrhea(CIA) is a objective process,the reason is clear basically,for patients with hormonal receptor positive will improve disease free survival and overall survival when develop CIA,so we can prevent ovarian function for patients have lower risk and intend to keep bearing ability;and further treatment inhibit ovarian function for improving outcome in patients with high risk and poor prognosis without CIA developed;CIA is an objective and simply observed factor.