硬膜外注射糖皮质激素治疗腰椎间盘突出症疗效的回顾性分析

目的:评估抗抑郁药治疗带状疱疹后神经痛的疗效。方法:90例带状疱疹后神经痛患者随机分为对照组(n=47)和试验组(n=43)。对照组采用常规疗法包括:药物治疗、物理治疗和微创治疗等。试验组在对照组的基础上加用抗抑郁药帕罗西汀20 mg,每天一次。采用视觉模拟评分法(visual an-alogue scale,VAS)分别于治疗前和治疗第30天评估疼痛强度,并计算疼痛缓解率。结果:两组治疗后比治疗前疼痛强度均显著降低(P<0.05),治疗后组间比较,试验组疼痛缓解率显著高于对照组(P<0.05)。结论:抗抑郁药帕罗西汀可有效提高带状疱疹后神经痛的疗效。

A RETROSPECTIVE ANALYSIS OF EPIDURAL STEROID INJECTION FOR LUMBAR INTERVERTEBRAL DISK HERNIATION

Objective:To evaluate the efficacy of antidepressant in the treatment of postherpetic neuralgia(PHN).Metheds: 90 PHN patients were randomized into control group(n = 47)(conventional therapies such as anticonvulsants,opioids,nerve blockade,superlaser and so on) and paroxetine-treatment group(n = 43)(conventional therapies plus paroxetine 20 mg,qd).Pain intensity was evaluated with visual analogue scale(VAS) before and 30 days after treatment.Results: Compared with before treatment,the intensity of PHN patients decreased after treatment in both group(P < 0.05).The remission rate of pain intensity in paroxetine-treated group was higher than that in control group(P < 0.05).No serious paroxetine-related adverse effects were found.Conclusion: Antidepressant can improve the efficacy of conventional therapies in the treatment of PHN.