| 凋亡相关基因产物Fas／APO—1和bcl—2蛋白在肾癌组织中的表达及 … |
| |
| 引用本文： | Li H,Yu L,Yang B,Kong X,Mi P,Guo Y. 凋亡相关基因产物Fas／APO—1和bcl—2蛋白在肾癌组织中的表达及 …[J]. 中华外科杂志, 1998, 36(7): 409-411 |
| |
| 作者姓名： | Li H Yu L Yang B Kong X Mi P Guo Y |
| |
| 摘 要： | 目的 研究凋亡相关基因Ｆａｓ／ＡＰＯ－１和ｂｃｌ－２在肾癌发生发展中的作用。方法 采用免疫组织化学法对３５例肾癌组织和２６例远离肾癌的正常肾组织Ｆａｓ／ＡＰＯ－１和ｂｃｌ－２蛋白的表达进行检测。结果 肾癌组织Ｆａｓ／ＡＰＯ－１蛋白表达率５７．１４％,明显低于正常肾组织中的表达率（８４．６２％,Ｐ〈０．０５）,且表达强度也明显低下;而ｂｃｌ－２蛋白表达率为８０．０％,明显高于正常肾组织中的表达率（５
|
| 关 键 词： | 肾肿瘤 细胞凋亡 Fas／APO－1 bcl－2基因 |
Expression and significance of Fas/APO-1 and bcl-2 protein in renal cell carcinoma |
| |
| Li H,Yu L,Yang B,Kong X,Mi P,Guo Y. Expression and significance of Fas/APO-1 and bcl-2 protein in renal cell carcinoma[J]. Chinese Journal of Surgery, 1998, 36(7): 409-411 |
| |
| Authors: | Li H Yu L Yang B Kong X Mi P Guo Y |
| |
| Affiliation: | Institute of Urology, First Teaching Hospital, Beijing Medical University, Beijing 100034. |
| |
| Abstract: | OBJECTIVE: To investigate the role of Fas/APO-1 and bcl-2 in occurrence and progression of renal cell carcinoma. METHOD: Immunohistochemistry method was used to detect the expression of Fas/APO-1 and bcl-2 protein in 35 cases of renal cell carcinoma tissues and 26 cases of normal renal tissues. RESULT: The expression rate of Fas/APO-1 protein in renal cell carcinoma tissues was 57.14%, significantly lower than that in normal renal tissues (84.62%) (P < 0.05), and the intensity of expression was also lower. The expression rate of bcl-2 protein reached 80.00%, much higher than that in normal renal tissues (53.85%) (P < 0.05). CONCLUSION: Both Fas/APO-1 and bcl-2 take part in the occurrence and progression of renal cell carcinoma. |
| |
| Keywords: | |
| 本文献已被 维普 PubMed 等数据库收录！ |
|
