电针"内关"对心肌缺血再灌注损伤内皮素及超微结构的影响

目的：探讨“内关”在心肌缺血再灌注损伤过程中对心肌细胞的保护作用。方法：电针家兔左右侧“内关”穴20min后，结扎左冠状动脉前降支，心电图（ECG）监测。40min后恢复灌流，再灌注1小时，取静脉血及心肌组织，观察血浆内皮素（ET）及透射电镜下组织超微结构的变化，结果：针刺“内关”组ET含量明显降低（P＜0．01），心肌组织损伤轻微，肌纤维正常走向，少量线粒体空泡变，肌丝无明显坏死，溶解，结论：电针“内关”可明显降低缺血再灌注损伤的程度，对心肌呈现良好的保护作用。

Effect of Electroacupuncture on Endothelin Content and Myocardial Ultrastructures in Myocardial Ischemia and Reperfusion Injury

Purpose To explore the protective action of acupuncture at 'Neiguan' (PC 6) on myocardial cells in the process of myocardial ischemia and reperfusion injury. Methods Acupuncture was given at 'Neiguan' (PC 6) for 20 min, followed by ligation of anterior descending branch of the left coronary artery and 40 min later, reperfusion for one hour, with ECG monitoring. Then, venous blood and myocardial tissue were taken and changes of plasma endothelin (ET) content and ultrastructures were observed. Results In the acupuncture group, ET content decreased significantly ( P <0 01), less injury of myocardial tissue, normal run of myocardial fiber, a small amount mitochondrial vacuolation, and no obvious dissolution and necrosis of myocardium were found. Conclusion Acupuncture at 'Neiguan' (PC 6) can obviously reduce the degree of myocardial ischemia and reperfusion injury, showing a good protective action on myocardium.