神经系统肿瘤恶性程度与其基因产物表达的不稳定性相关

用免疫组化法检测了１０例中枢神经系统肿瘤和１０例末梢神经系统肿瘤细胞中ＰＣＮ，Ａｂｃｌ－２，Ｆａｓ，ＢＭ－１，Ｒｂ和ｐ５３基因产物的表达。ＰＣＮＡ，ｂｃｌ－２，Ｆａａ，ＢＭ－１，Ｒｂ和ｐ５３在中枢神经系统肿瘤中分别有７，１，４，０，２，３，例阳性；而在末梢神经系统肿瘤中则各有４，５，１０，０，５，０例阳性。在两者之间存在基因产物表达上的差异。

Gene product expression associated with malignancy of neural neoplasia

Tumor cells in 10 central neural tumors and 10 peripheral neural tumors were examined immunohistologically by ABC method using specific antibodies to PCNA,bcl-2,Fas,BM-1,Rb and p53.Tumor cells gave positive reactions in 7,1,4,0,2and 3 cases in central neural tumors and in 4,5,10,0,5 and 0 cases in peripheral neural tumors in the test with PCNA,bcl-2 Fas BM-1,Rb and p53,respectively.Tumors positive for both PCNA and bcl-2 had poor outcome.The expression of certain gene products associated with growth regulation may be useful for estimating the malignancy of neural tumors.