| p16甲基化在宫颈癌癌变中的作用研究 |
| |
| 引用本文： | 梁月勉,何春年. p16甲基化在宫颈癌癌变中的作用研究[J]. 医学综述, 2008, 14(18): 2783-2785 |
| |
| 作者姓名： | 梁月勉 何春年 |
| |
| 作者单位： | 河北省人民医院病理科,石家庄,050051 |
| |
| 摘 要： | p16基因又称多肿瘤抑制基因,是人们发现的第一个直接作用于细胞周期,抑制细胞分裂的基因。DNA甲基化是抑癌基因失活的机制,p16基因甲基化及其在子宫颈癌癌变中的作用机制还不清楚。本文对宫颈癌中p16基因甲基化的相关研究内容进行综述。
|
| 关 键 词： | p16基因 DNA甲基化 宫颈癌 |
The Methylation Investigation of p16 Effect in Cervical Carcinomas |
| |
| LIANG Yue-mian,HE Chun-nian. The Methylation Investigation of p16 Effect in Cervical Carcinomas[J]. Medical Recapitulate, 2008, 14(18): 2783-2785 |
| |
| Authors: | LIANG Yue-mian HE Chun-nian |
| |
| Affiliation: | LIANG Yue-mian,HE Chun-nian.(Department of Pathology,Hebei Provincial People's Hospital,Shijiazhuang 050051,China) |
| |
| Abstract: | p16 gene is a multiple tumor suppressor.It is the first anti-oncogene which directly effects cell cycle to suppress division of cells.The mechanism of antioncogene inactivation is DNA methylation.p16 gene methylation in cervical cancer and the mechanisms are still unclear.In this paper,the related contents of methylation of p16 gene in cervical cancer were reviewed. |
| |
| Keywords: | p16 DNA methylation Cervical carcinomas |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
