环磷酸腺苷葡甲胺治疗病态窦房结综合征疗效研究

目的评价环磷酸腺苷葡甲胺（即心先安）对病态窦房结综合征（病窦）的疗效及治疗价值。方法采用随机单盲对照法，对152例病窦分为治疗组和对照组，两组分别静脉点滴心先安和黄芪注射液，15d后比较两者临床、心电图和食管电生理的变化。结果（1）临床疗效治疗组和对照组总有效率分别是86.7%和49.2%，两组差异有显著性（P<0.01）;（2）体表心电图和24h动态心电图治疗组和对照组总有效率分别是84.3%和40.5%，其24h心率总数分别是(89360±5987)次/min和(64321±4170)次/min，统计学比较有明显差异（P<0.01）;（3）食管电生理检查窦房结功能窦房结恢复时间、校正后窦房结恢复时间和窦房结传导时间，在治疗组的治疗后与治疗前相比较以及与对照组的治疗前后相比较，治疗组中治疗后有明显提高心率的作用（P<0.01）。结论心先安治疗病窦有明显疗效，近期疗效好，副作用少，其远期疗效有待观察。

Curative effect of meglumine cyclic adenylate on sick sinus syndrome

Objective　To evaluate the curative effect and clinical value of meglumine cyclic adenylate (MCA) on sick sinus syndrome. Methods　152 patients with sick sinus syndrome were divided in to two groups. 83 patients were given MCA by intravenous driping for 15 days as treatment group, the other 69 patients were given radix astragali for 15 days as control group. Compared the changes of clinical expression, electrocardiogram (ECG and DCG ) and esophagus electrophysiological study in the two groups with randomized single blind comparative analysis. Results　1. Clinical curative effect: The total effective rate of the MCA group was 86.7%, while that of the astragalux group was 49.2%. There was evident difference between them (P<0.01). 2. ECG and DCG: The total effective rate of the treatment group was 84.3%,and that of control group was 40.5%. The total heart rate of 24 hours was (89360±5987)/min and (64321±4170)/min, respectively (P<0.01). 3.Esophagus electrophysiological study in sinus node function: The sinus node recovery time (SNRT), correct sinus node recovery time (cSNRT) and sinus atrial conduction time (SACT) of the treatment group were improved evidently (P<0.01). Conclusion　There is evident short-term, curative effect of MCA on sick sinus syndrome without side effect but the long-term effect remains to be studied.