| 微RNA与肿瘤 |
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| 引用本文： | 贺小停. 微RNA与肿瘤[J]. 国外医学(肿瘤学分册), 2010, 0(12): 883-885 |
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| 作者姓名： | 贺小停 |
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| 作者单位： | 无锡市人民医院肿瘤内科,214001 |
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| 摘 要： | 微RNA（miRNA）是一类非编码的小RNA分子,通过直接抑制基因转录或蛋白质的表达而在器官发育,细胞增殖、分化和凋亡等多种生理过程中发挥关键作用.miRNA异常表达往往导致包括肿瘤在内的多种疾病.研究发现,miRNA在肿瘤发生发展、侵袭转移及肿瘤的诊治中起着重要作用.
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| 关 键 词： | 微RNAs 肿瘤 肿瘤转移 治疗 |
MicroRNA and cancer |
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| HE Xiao-ting. MicroRNA and cancer[J]. Foreign Medical Sciences (Cancer Section), 2010, 0(12): 883-885 |
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| Authors: | HE Xiao-ting |
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| Affiliation: | HE Xiao-ting( 1.Oncology Department, Wuxi Ppeople＇s Hospital, Wuxi 210400, China;) |
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| Abstract: | MicroRNAs （MiRNAs） are a contemporary class of short non-coding RNAs,which play a critical role in diverse biological processes, including development, cell proliferation, differentiation, and apoptosis,by suppressing translation of protein coding genes, or cleaving target mRNAs of protein coding genes to induce their degradation. Accordingly, altered miRNA expression is likely to contribute to human disease, including cancer. This review will summarize the emerging knowledge of the association between human miRNA biology and different aspects of carcinogenesis, such as the development, metastesis and therapy strategies. |
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| Keywords: | MicroRNAs Neoplasms Neoplasm metastasis Therapy |
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