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Effect of Concomitantly Administered Drugs on the Control of Long Term Anticoagulant Therapy |
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| Authors: | WILLIAMS J R B; GRIFFIN J P; PARKINS ANNE |
| Abstract: | The stability of control of long term anticoagulant therapywas studied in a group of 277 patients with respect to druginteractions. Increased instability (changes of dose/month oftherapy) was related to the number of concomitant drugs takenirrespective of, and in addition to, known specific interactions.Fluctuating cardiac status in patients requiring digoxin anddiuretic therapy was a major factor in stabilizing anticoagulantcontrol. |
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