高血压患者糖耐量与超敏C反应蛋白的相关性

目的通过对不同糖耐量水平的原发性高血压患者的血浆超敏C反应蛋白(hsCRP)水平进行比较,探讨hsCRP与原发性高血压患者糖耐量水平的相关性。方法按条件入选原发性高血压患者146例,行葡萄糖耐量试验(OGTT)、血脂及hsCRP检测,根据糖耐量水平分为3组:糖耐量正常(NGT)组、糖耐量异常(IGT)组和2型糖尿病(T2DM)组。结果(1)3组患者之间在年龄、性别、体重、收缩压(SBP)、舒张压(DBP)、体重指数(BMI)、低密度脂蛋白胆固醇(LDL-C)及甘油三酯(TG)等指标上均无显著性的统计学差异,具有较好的可比性;(2)3组患者之间的hsCRP水平逐渐升高,组间比较有明显差异性(P<0·01)。原发性高血压患者糖耐量越差则血浆hsCRP水平越高(r=0·72,P<0.05)。结论对伴有hsCRP升高的原发性高血压患者行OGTT检查可早期发现糖耐量异常,及时给予针对性干预治疗。

Plasma hsCRP and Glucose Tolerance in Essential Hypertensive Patients

Objective To test the hypothesis that the plasma high sensitivity C-reactive protein (hsCRP) level in essential hypertensive patients were related with various degree of glucose tolerance. Methods One hundred forty six essential hypertensive patients were divided into NGT, IGT and T2DM groups according their OGTT results. Blood pressure and laboratory studies, including hsCRP level were determined. Results (1)Age, gender, body weight, BMI, SBP, DBP, LDL-C and TG index between three group were not significant different among groups; (2)The hsCRP level gradually increased from NGT to T2DM groups (P<0.01). Plasma hsCRP level was positively correlated with glucose tolerance degree in essential hypertension patients(r=0.72, P<0.05). Conclusion hsCRP was related with the abnormal glucose tolerance in essential hypertensive patients. Essential hypertension patients with high level of hsCRP should be underwent OGTT test to find out the glucose tolerance status and appropriate treatment should be administered.