Regional Assessment of Cone System Function Following Uncomplicated Retinal Detachment Surgery |
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Authors: | Lucrezia?Montrone Lucia?Ziccardi Giovanna?Stifano Marco?Piccardi Fernando?Molle Francesco?Focosi Antonello?Fadda Email author" target="_blank">Benedetto?FalsiniEmail author |
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Institution: | (1) Institute of Ophthalmology, Catholic University, Rome, Italy;(2) Biomedical Engineering Lab., I.S.S., Rome, Italy;(3) Institute of Ophthalmology, Catholic University, L.go F. Vito 1, Rome, 00168, Italy |
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Abstract: | Purpose: To evaluate regional cone system function after uncomplicated retinal detachment (RD) surgery, by recording focal electroretinograms
(FERGs) from the central and paracentral regions of the posterior pole. Methods: FERGs in response to either a central (eccentricity: 0–2.25 deg) or a paracentral annular (2.25–9 deg) uniform field, presented
on a light adapting background and sinusoidally flickered at 41 Hz (95% modulation depth, 93 cd/m2 mean luminance) were recorded from 16 eyes (16 patients) 2 weeks to 420 months following uncomplicated RD surgery (encircling
procedure with or without scleral buckling). Pre-operatively, 10 out of 16 eyes had a macular RD. Mean time elapsed from onset
of symptoms to surgery was 20 days (range: 5–90 days). Post-operatively, visual acuity ranged 0.1 to 1.0. Eight age-matched
normal subjects served as controls. Amplitude and phase of the FERG fundamental harmonic were measured. Results: Compared to control eyes, affected eyes’ central and paracentral FERGs were on average reduced in amplitude (by 40% and 28%,
respectively, p<0.01) and delayed in phase (by 70 and 100 degrees, respectively, p<0.01). Eyes with a macular RD did not differ in FERG amplitude or phase from eyes that had a peripheral RD. In individual
affected eyes, central, but not paracentral FERG amplitudes were negatively correlated (p=0.05) with time elapsed from onset of symptoms to surgery. Conclusions: Central and paracentral cone system dysfunction may be detected even at lengthy time intervals from retinal reattachment,
independent of the presence of a pre-operative macular RD. The extent of central loss appears to be inversely related to RD
duration, in agreement with previous reflectometric findings on foveal cone photopigment density Liem et al., 1994; Ophthalmology
10: 1945-51]. |
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Keywords: | cone system focal electroretinogram functional recovery retinal detachment surgery |
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