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Insights into the potential role of alpha1-antitrypsin in COVID-19 patients: Mechanisms,current update,and future perspectives |
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| Authors: | Saber Marzouk Noha Attia Mohamed Mashal |
| Affiliation: | 1. Department of Pharmacy, Ministry of Health, Mallawi, El Minia, Egypt;2. The American University of Antigua-College of Medicine, University Park, Coolidge, Antigua and Barbuda NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country (UPV/EHU), Vitoria-Gasteiz, Spain Department of Medical Histology and Cell Biology, Faculty of Medicine, University of Alexandria, Alexandria, Egypt;3. The American University of Antigua-College of Medicine, University Park, Coolidge, Antigua and Barbuda |
| Abstract: | In this work, we provide an up-to-date summary of the available molecular- and cell-related mechanisms by which alpha1-antitrypsin (AAT) protein could be of benefit in treating COVID-19 patients. As well, we demonstrate the current status in terms of the ongoing clinical trials using AAT in COVID-19 patients. Finally, we touch on the potential role gene therapy and stem cell-based gene therapy could have in such emerging and serious condition caused by the SARS-CoV-2 virus. |
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