| 严重烫伤大鼠肠粘膜通透性改变及其机理 |
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| 引用本文： | 余佩武,肖光夏,府伟灵,周立新,秦孝健. 严重烫伤大鼠肠粘膜通透性改变及其机理[J]. 中华整形外科杂志, 1996, 0(5) |
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| 作者姓名： | 余佩武 肖光夏 府伟灵 周立新 秦孝健 |
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| 作者单位： | 第三军医大学西南医院烧伤研究所，西南医院普外科 |
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| 摘 要： | 采用９９ｍＴｃ－ＤＴＰＡ血至肠腔清除率定量测定方法，观察大鼠严重烫伤后肠粘膜通透性的变化规律及血小板活化因子（ＰＡＦ）对其产生的影响，以探讨严重烫伤后肠粘膜屏障功能损害的病理生理过程及机理。结果表明：严重烫伤后肠粘膜通透性显著升高，与肠组织ＰＡＦ含量升高呈显著正相关（ｒ＝０．９４，Ｐ＜０．０１），ＰＡＦ拮抗剂治疗能明显降低肠粘膜通透性。提示，ＰＡＦ是导致严重烫伤后肠粘膜通透性升高的重要因素之一。
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| 关 键 词： | 烧伤 肠 通透性 血小板 活化因子 |
A study on changes and its mechanisms of intestinal mucosal permeability after severe burn |
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| Yu Peiwu, Xiao Guangxia,Fu Weiling ,et al.. A study on changes and its mechanisms of intestinal mucosal permeability after severe burn[J]. Chinese journal of plastic surgery, 1996, 0(5) |
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| Authors: | Yu Peiwu Xiao Guangxia Fu Weiling et al. |
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| Abstract: | The changes in the intestinal mucosal permeability were observed by quantitatively assessing plasma to luminal clearance of (99m)Tc-labeled DTPA, and the influence of platelet activating factor (PAF) on it was investigated. The results showed that intestinal permeability was significantly elevated after severe burn and was positively correlated with increase in PAF in the intestinal tissue (r=0. 94, P<0. 01). PAF antagonist therapy could significantly attenuate postburn intestinal mucosal permeability. It is concluded that PAF is one of the important factors causing increased intestinal permeability after severe burn. |
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| Keywords: | Burn Intestinal permeability Platelet activating factor |
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