| 双脱甲氧基姜黄素脂质体对体外培养人肺腺癌A549细胞增殖活性的影响研究 |
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| 引用本文： | 宫亮,杨和平,王昆,李剑明,周向东. 双脱甲氧基姜黄素脂质体对体外培养人肺腺癌A549细胞增殖活性的影响研究[J]. 中国药房, 2006, 17(20): 1537-1539 |
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| 作者姓名： | 宫亮 杨和平 王昆 李剑明 周向东 |
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| 作者单位： | 1. 第三军医大学西南医院,重庆市,400038
2. 第三军医大学基础医学部病原生物学教研室,重庆市,400038 |
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| 摘 要： | 目的:考察双脱甲氧基姜黄素脂质体对体外培养人肺腺癌A549细胞增殖活性的影响。方法:将双脱甲氧基姜黄素脂质体作用于体外培养人肺腺癌A549细胞,分别应用形态学观察、MTT检测、流式细胞仪检测观察其生长形态、细胞周期等生物学特性变化。结果:显微镜下可见A549细胞形态明显改变;双脱甲氧基姜黄素脂质体对A549细胞增殖有抑制作用,其IC50为12.108μg/ml;流式细胞仪显示细胞周期阻滞在S期。结论:双脱甲氧基姜黄素脂质体可抑制人肺腺癌A549细胞的增殖,在肺腺癌治疗中有一定应用前景。
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| 关 键 词： | 双脱甲氧基姜黄素脂质体 人肺腺癌 A549细胞 增殖活性 |
| 文章编号： | 1001-0408(2006)20-1537-03 |
| 收稿时间： | 2006-03-10 |
| 修稿时间： | 2006-07-20 |
Effect of Liposome - encapsulated Bisdemethoxycurcumin on the Proliferation of Human Lung Adenocarcinoma Cell Line A549 |
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| GONG Liang,YANG Heping,WANG Kun,LI Jianming,ZHOU Xiangdong. Effect of Liposome - encapsulated Bisdemethoxycurcumin on the Proliferation of Human Lung Adenocarcinoma Cell Line A549[J]. China Pharmacy, 2006, 17(20): 1537-1539 |
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| Authors: | GONG Liang YANG Heping WANG Kun LI Jianming ZHOU Xiangdong |
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| Affiliation: | Southwest Hospital, The Third Military Medical University, Chongqing 400038, China;Dept. of Medical Parasitology, The Third Military Medical University, Chongqing, 400038, China |
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| Abstract: | OBJECTIVE:To investigate the effect of liposome-encapsulated demethoxycurcumin on the proliferation of human lung adenocarcinoma cell line A549.METHODS:The in vitro cultured human lung adenocarcinoma cell line A549 was treated with liposome-encapsulated Bisdemethoxycurcumin.The bionomics including morphology and cell cycle of cell line A549 were observed by morphological analysis,MTT assay and flow cytometry assay.RESULTS:Marked morphological changes were noted in cell line A549 under microscope.Liposome-encapsulated Bisdemethoxycurcumin showed inhibitory action on the growth of A549 cell lines,with IC50 at 12.108μg/mL.The progression of cell cycle was arrested in S phase.CONCLUSION:Liposome-encapsulated Bisdemethoxycurcumin can inhibit the growth of human lung adenocarcinoma cell line A549,which has a promising future in the treatment of adenocarcinoma of lung. |
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| Keywords: | Bisdemethoxycurcumin liposome Adenocarcinoma of lung Cell line A549 Proliferation |
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