GnRH免疫活性细胞和神经在大鼠胃肠胰系统分布的初步研究

本研究用免疫金银法。对促性腺激素释放激素(GnRH)免疫活性细胞和神经在大鼠胃肠胰系统的分布,进行了研究。在胃、小肠、大肠和胰腺有GnRH免疫反应阳性的上皮细胞,这些细胞的顶端到达腺腔面或器官腔面,属于开放型的内分泌细胞。在胃和小肠的肌间神经丛、粘膜下神经丛和浆膜下,有GnRH免疫活性神经细胞。在小肠的粘膜下层和固有层,有GnRH免疫活性神经纤维。这些结果提示,GnRH对消化生理可能有重要的意义。

PRELIMINARY STUDY OF THE DISTRIBUTION OF GnRH IMMUNOREACTIVE CELLS AND NERVES IN GASTRO-ENTERO-PANCREATIC SYSTEM OF RATS

Distribution of GnRH immunoreactive cells and nerves in gastro entro-pancreatic system of rats was studied by using immunogold-silver staining. The GnRH immunoreactive epithelial cells can be seen in the stomach, small intestine, large intestine and pancreas. The apical portion of these GnRH postive epithelial cells extended to the luminal surface of surface epithelium and glands, and they belong to the open type endocrine cells. The GnRH immunoreactive nerve cells can be found in submucous plexus, myenteric plexus and serosa of the stomach and small intestine. The GnRH postive nerve fibers can be seen in lamina propria and submucosa of the small intestine. These results suggest that the GnRH may play an important role in the regulation of digestion.