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| 基于Ras信号转导途径的药物靶标研究进展 | |
| 引用本文： | 刘雪梅,邓平,费良润,谢建平,王洪海. 基于Ras信号转导途径的药物靶标研究进展[J]. 药学进展, 2008, 32(11): 481-487 |
| 作者姓名： | 刘雪梅 邓平 费良润 谢建平 王洪海 |
| 作者单位： | 1. 西南大学生命科学学院,重庆,400715 2. 西南大学生命科学学院,重庆,400715;复旦大学生命科学学院遗传学研究所,遗传工程国家重点实验室,上海,200433 3. 复旦大学生命科学学院遗传学研究所,遗传工程国家重点实验室,上海,200433 |
| 基金项目： | 国家重大基础研究规划(973)项目，教育部科学技术研究重点项目，211微生物学科重点建设项目 |
| 摘 要： | 综述ras基因及Ras蛋白的结构和主要功能，尤其是Ras蛋白在细胞分裂、增殖、凋亡等方面所起的重要作用，并着重概述Ras信号转导网络以及基于这些信号转导途径的抗肿瘤和抗微生物药物靶标研究。ras基因及其编码的Ras蛋白参与体内多种信号转导途径，在细胞信号传递中发挥“分子开关”作用，是信号转导的重要组织者。 |
| 关 键 词： | RAS基因 RAS蛋白 信号转导途径 药物靶标 |
Potential Drug Targets Based on the Ras Signal Transduction Pathways:a Review |
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| LIU Xue-mei,DENG Ping,FEI Liang-run,XIE Jian-ping,WANG Hong-hai. Potential Drug Targets Based on the Ras Signal Transduction Pathways:a Review[J]. Progress in Pharmaceutical Sciences, 2008, 32(11): 481-487 | |
| Authors: | LIU Xue-mei DENG Ping FEI Liang-run XIE Jian-ping WANG Hong-hai |
| Affiliation: | LIU Xue-mei1,DENG Ping1,FEI Liang-run1,XIE Jian-ping1,2,WANG Hong-hai2(1.School of Life Sciences,Southwest University,Chongqing 400715,China,2.State Key Laboratory of Genetic Engineering,Institute of Genetics,School of Life Sciences,Fudan University,Shanghai 200433,China) |
| Abstract: | ras Genes and the structure and major functions of ras-encoded Ras proteins, especially including their key role in cell division, proliferation and apoptosis, were reviewed. Ras signaling network and the potential targets for anti-tumor and anti-microorganism were emphatically summarized, ras and its products Ras proteins are involved in multiple signal transduction pathways and play a pivotal role of the molecular switch and integrator therein. |
| Keywords: | ras Gene Ras protein Signal transduction pathway Drug target |
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