X-linked retinoschisis is closely linked to DXS41 and DXS16 but not DXS85 |
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| Authors: | Tiina,Alitalo ,Jussi,Kä rnä ,Henjik,Forsius Albert,de la Chapelle |
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| Affiliation: | Department of Medical Genetics, University of Helsinki;Department of Ophthalmology, University of Oulu;Folkhälsan Institute of Genetics, Finland |
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| Abstract: | A linkage study was carried out in nine families with 24 males affected by X-linked recessive retinoschisis (RS), using three polymorphic DNA probes from the distal segment of Xp. Close linkage of the disease locus with markers DXS41 (probe p99-6) and DXS16 (pXUT23) was found, confirming the location of the RS gene on the distal short arm of the X chromosome. Lod scores for linkage with DXS85 (probe 782) were negative. |
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| Keywords: | DNA DXS16 DXS41 DXS85 linkage retinoschisis RFLP X chromosome |
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