Tumoricidal activation of murine resident peritoneal macrophages on pancreaticcarcinoma by interleukin-2 and monoclonal antibodies |
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Authors: | Chen Qi-Kui Yuan Shi-Zhen Zeng Zhi-Yong Huang Zhi-Qing |
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Affiliation: | Department of Gastroenterology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou 510120,Guangdong Province, China |
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Abstract: | INTRODUCTION Macrophages play an important role in tumor lysis and growth inhibition. They can be activated to a tumoricidal state by a variety of agents such as IFNr, TNFa or IL2. The killing machanisms of activated macrophages have been extensively investigated[1,2]. Recently, it has been proved that antibody dependent cellular cytotoxicity (ADCC) is one of the potent arms to lyse tumor cells resistant to cytotoxic macrophages,and that the antitumorous effect of a macrophage activator is significantly augmented by the combined use of mAbs capable of inducing ADCC to tumor cells[3]. |
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Keywords: | pancreatic neoplasms/therapy antibody,monoclonal/therapeutic use macrophages,lymphokine cytotoxicity,immunologic interleukin-2 |
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