虎杖口服液对慢性阻塞性肺疾病伴肺动脉高压的临床疗效研究

目的 探讨虎杖对慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)伴肺动脉高压患者的血流动力学及血栓素B2、6-酮-前列腺素F1a的影响,明确虎杖口服液的临床疗效.方法 在我院住院病人中选取COPD伴肺动脉高压的急性期患者60例,随机分为对照组(32例)和虎杖组(2...

Clinical Effectiveness of Poligonum Cuspidatum in COPD with Pulmonary Hypertension

OBJECTIVE To investigate the effect of Poligonum cuspidatum on hemodynamics and TXB2,6-Keto-PGF1α in chronic obstructive pulmonary disease（COPD） with pulmonary hypertension.METHODS Sixty acute exacerbation of COPD patients with pulmonary hypertension were randomized into two groups： control group（32 patients） and Huzhang group（28 patients）.The control group received ordinary therapy,and Huzhang group received extra Poligonum cuspidatum.The pulmonary artery pressure,heart rate,mean systemic artery pressure,TXB2,and 6-Keto-PGF1α were measured before and after treatment.RESULTS In control group,there was no significant decrease of pulmonary and systemic artery pressure,and no significant changes（P0.05） were found in TXB2 and 6-Keto-PGF1α,but the heart rate was decreased（P0.01）.In Huzhang group,pulmonary artery pressure was significantly decreased（P0.05）,but the heart rate was similar to control group（P0.05）,and the mean systemic artery pressure had no changes（P0.05）.The levels of TXB2 were decreased（P0.05） but of 6-Keto-PGF1α were increased（P0.05）.CONCLUSION The results suggest that Poligonum cuspidatum can significantly decline pulmonary artery of COPD with pulmonary hypertension and TXB2.