| 苦参碱磁性缓释颗粒的制备及性能研究 |
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| 引用本文： | 谢明全,张玲玲,黄媛梅,李平,李玉民.苦参碱磁性缓释颗粒的制备及性能研究[J].中国生化药物杂志,2012,33(6):706-708,712. |
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| 作者姓名： | 谢明全 张玲玲 黄媛梅 李平 李玉民 |
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| 作者单位： | 1. 兰州大学 第二医院,甘肃兰州730030;甘肃省消化系统肿瘤重点实验室,甘肃兰州730030
2. 兰州大学 第二医院,甘肃兰州730030;;兰州大学 药学院,甘肃兰州730000 |
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| 基金项目： | 天津市东丽区人民政府创业苗圃专项资助项目，甘肃省科技计划项目，甘肃省消化系肿瘤重点实验室项目 |
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| 摘 要： | 目的制备苦参碱磁性缓释颗粒,并对其性能进行研究。方法以壳聚糖、Fe3O4纳米粒为主要材料,采用L9(34)正交试验法优选制备工艺,并评价其性能。结果正交设计获最优处方为:微晶纤维素质量0.40 g,壳聚糖浓度2.0%,壳聚糖质量0.25 g,磁性纳米粒质量为0.12 g,药物体外释放行为符合一级动力学方程,并具有明显的磁敏感性。结论该制剂制备工艺合理可行,有较好的缓释效果和顺磁性,可作为消化系肿瘤治疗的给药剂型。
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| 关 键 词： | 苦参碱 磁性缓释颗粒 壳聚糖 Fe3O4纳米粒 释放度 |
Study on preparation and properties of magnetic sustained release granules loaded matrine |
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| XIE Ming-quan
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ZHANG Ling-ling
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HUANG Yuan-mei
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LI Ping
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LI Yu-min.Study on preparation and properties of magnetic sustained release granules loaded matrine[J].Chinese Journal of Biochemical Pharmaceutics,2012,33(6):706-708,712. |
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| Authors: | XIE Ming-quan ZHANG Ling-ling HUANG Yuan-mei LI Ping LI Yu-min |
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| Institution: | 1,2(1.No.2 Hospital of Lanzhou University,Lanzhou 730030,China;2.Key Laboratory of Digestive System Tumors,Lanzhou 730030,China;3.Pharmacy School,Lanzhou University,Lanzhou 730000,China) |
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| Abstract: | Purpose To prepare the magnetic sustained release granules loaded matrine and to evaluate its properties.Methods Using chitosan and Fe3O4 nanoparticles as major matrix,the optimal formulation of matrine magnetic sustained release granules was selected by L9(34) orthogonal design.Also,its properties were estimated.Results The best recipe was as follows:MCC 0.40 g,chitosan concentration 2.0%,chitosan 0.25 g and Fe3O4 nanoparticles 0.12 g.The release behavior followed the first-order kinetics,and occupated significant magnetic sensitive characteristics.Conclusion The results showed that magnetic sustained release granules loaded matrine have a good sustained release effect and paramagnetism and the preparation process is rational and practicable.This product could be used as a new therapeutic dosage form for digestive system tumor. |
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| Keywords: | matrine magnetic sustained release granules chitosan Fe3O4 nanoparticles release |
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