| 恩替卡韦对慢性乙型肝炎患者外周血B淋巴细胞亚群的影响 |
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| 引用本文： | 周文兴,吕国良,于渤,刘馨. 恩替卡韦对慢性乙型肝炎患者外周血B淋巴细胞亚群的影响[J]. 中国生化药物杂志, 2012, 33(6): 888-889 |
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| 作者姓名： | 周文兴 吕国良 于渤 刘馨 |
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| 作者单位： | 1. 辽宁医学院 附属第一医院,辽宁锦州,121001
2. 辽河油田妇婴医院,辽宁盘锦,124120 |
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| 摘 要： | 目的探讨恩替卡韦抗病毒治疗对慢性乙型肝炎患者外周血B淋巴细胞亚群的影响。方法慢性乙型肝炎患者60例,随机分为对照组、治疗组各30例。对照组仅给予常规治疗,治疗组另外给予恩替卡韦0.5 mg/d,口服,疗程48周。检测治疗前后患者外周血CD5+B细胞(CD5+,CD19+)及传统B细胞(CD5-,CD19+)百分率。结果对照组治疗前后外周血CD5+B淋巴细胞百分率无明显变化,治疗组治疗后较治疗前明显下降,且明显低于对照组(P<0.05)。结论恩替卡韦治疗对于慢性乙型肝炎患者体液免疫失衡有改善作用。
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| 关 键 词： | 恩替卡韦 慢性乙型肝炎 B淋巴细胞 |
Effect of Entecavir on peripheral blood B lymphocyte subsets in chronic hepatitis B patients |
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| ZHOU Wen-xing , LU Guo-liang , YU Bo , LIU Xin. Effect of Entecavir on peripheral blood B lymphocyte subsets in chronic hepatitis B patients[J]. Chinese Journal of Biochemical Pharmaceutics, 2012, 33(6): 888-889 |
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| Authors: | ZHOU Wen-xing LU Guo-liang YU Bo LIU Xin |
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| Affiliation: | 1(1.The No.1 Affiliated Hospital of Liaoning Medical University,Jinzhou 121001,China; 2.Maternal and Childen Health Hospital of Liaohe Oil Field,Panjin 124120,China) |
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| Abstract: | Purpose To analysis the effect of Entecavir on peripheral blood B lymphocyte subsets in chronic hepatitis B patients.Methods 60 patients were randomly divided into treatment group and control group.Patients in treatment group were received Entecavir O.5 mg/d for 48 weeks.The percentages of CD5+B cells(CD5+,CD19+) and traditional B cells(CD5-,CD19+) were measured using immunofluorescence double-staining and flow cytometry.Results Compared with control group,treatment of Entecavir can reduce the percentages of peripheral blood CD5+B lymphocytes statistically.Conclusion Entecavir seemed to present corrective proper for the humoral immune imbalance of chronic hepatitis B patients. |
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| Keywords: | Entecavir chronic hepatitis B B lymphocyte |
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