Bryoanthrathiophene,a new antiangiogenic constituent from the bryozoan Watersipora subtorquata (d'Orbigny, 1852) |
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| Authors: | Jeong Sei-Joon Higuchi Ryuichi Miyamoto Tomofumi Ono Mayumi Kuwano Michihiko Mawatari Shunsuke F |
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| Affiliation: | Graduate School of Pharmaceutical Sciences and Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. |
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| Abstract: | A new antiangiogenic compound, bryoanthrathiophene (1), together with two known compounds, 5,7-dihydroxy-1-methoxycarbonyl-6-oxo-6H-anthra[1,9-bc]thiophene (2) and 1,8-dihydroxyanthraquinone (3), was isolated from the bryozoan Watersipora subtorquata (d'Orbigny, 1852) using bioassay-guided fractionation methods. Among them, bryoanthrathiophene (1) exhibited the most potent antiangiogenic activity on BAEC (bovine aorta endothelial cell) proliferation. |
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