| 中国乙肝病毒B基因亚型的分布 |
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| 引用本文： | 黄月华,周彬,王战会,马世武,梁敏锋,侯金林.中国乙肝病毒B基因亚型的分布[J].中华实验和临床病毒学杂志,2007,21(2):111-113. |
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| 作者姓名： | 黄月华 周彬 王战会 马世武 梁敏锋 侯金林 |
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| 作者单位： | 510515,广州,南方医科大学南方医院感染内科 |
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| 基金项目： | 国家自然科学基金(30500434) |
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| 摘 要： | 目的调查乙肝病毒B基因亚型在我国的分布情况。方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)法并结合测序法,对来自全国7个中心的共511份B基因型感染血清样本进行了检测。结果511份B基因型样本经亚型分析,确定全部为Ba亚型,未发现Bj亚型的存在。结论流行于我国南方及北方地区的乙肝病毒B基因型毒株绝大部分为Ba亚型,Bj亚型非常罕见。
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| 关 键 词： | 肝炎病毒 乙型 基因型 蛋白质亚型 |
| 收稿时间： | 2007-01-15 |
| 修稿时间： | 2007-01-15 |
Distribution of hepatitis B virus genotype B subgenotype in China |
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| HUANG Yue-hua,ZHOU Bin,WANG Zhan-hui,MA Shi-wu,LIANG Min-feng,HOU Jin-lin.Distribution of hepatitis B virus genotype B subgenotype in China[J].Chinese Journal of Experimental and Clinical Virology,2007,21(2):111-113. |
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| Authors: | HUANG Yue-hua ZHOU Bin WANG Zhan-hui MA Shi-wu LIANG Min-feng HOU Jin-lin |
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| Institution: | Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China |
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| Abstract: | Objective To investigate the distribution of hepatitis B virus (HBV) genotype B subgenotype in China. Methods A cohort of 511 patients with chronic HBV genotype B infection, collected from 7 centers across China, were analyzed by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) or nucleotide sequencing. Results For the 511 patients, only subgenotype Ba was identified and subgenotype Bj was not found. Conclusion In China, subgenotype Ba was the most prevalent HBV strains, while subgenotype Bj was very rarely found. |
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| Keywords: | Hepatitis B Virus Genotype Protein isoforms |
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