| 金斛春冲剂安全性毒理学评价 |
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| 引用本文： | 郑定仙,赵毓梅,黄业宇,林卫华. 金斛春冲剂安全性毒理学评价[J]. 中国热带医学, 2005, 5(2): 338-339,337 |
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| 作者姓名： | 郑定仙 赵毓梅 黄业宇 林卫华 |
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| 作者单位： | 海南省疾病预防控制中心,海南,海口,570203 |
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| 摘 要： | 目的对金斛春冲剂的食用安全性进行毒理学评价.方法采用急性毒性试验、遗传毒性试验(Ames试验、小鼠骨髓微核试验、小鼠精子畸形试验)、30d喂养试验进行检测评价.结果雌雄小鼠经口LD50均大于20.0g/kg体重,Ames试验、小鼠骨髓微核试验、小鼠精子畸形试验三项遗传毒性试验结果均为阴性.5.00g/kg体重之剂量30d喂养试验未见明显毒性作用.结论金斛春冲剂急性毒性分级属无毒级、无遗传毒性,初步估计最大无损害作用剂量大于5g/kg体重,相当于人体推荐摄入量的100倍.
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| 关 键 词： | 小鼠 冲剂 骨髓微核试验 精子畸形试验 Ames试验 遗传毒性试验 体重 安全性毒理学 剂量 食用安全性 |
| 文章编号： | 1009-9727(2005)02-338-02 |
Toxicological assessment of the edible safety of Jinhuchun granule |
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| ZHEN Ding-xian,ZHAO Yu-mei,HUANG Ye-yu,et al.. Toxicological assessment of the edible safety of Jinhuchun granule[J]. China Tropical Medicine, 2005, 5(2): 338-339,337 |
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| Authors: | ZHEN Ding-xian ZHAO Yu-mei HUANG Ye-yu et al. |
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| Abstract: | Objective To evaluate toxicologically the edible saf ty of Jinhuchun granule. Methods Acute toxity test,Ames test,Mi c ronucieus test,Sperm shape abnornality test and thirty days feeding test were pe rformed. Results The oral LD (50) in male or female mice w a s higher than 20.0g/kg.bw.Ames test,micronecleus test and sperm shape abnorma li ty were postive.No synificant toxicity was detected in Thirty days feeding test . Conclusion Jinhuchun granule has no acute toxicity,no genotox icity,maximal-no-observd-adverse-effect level(MNOAEL) is more than one handr ed times proposal daily intake amount in human. |
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| Keywords: | Jinhuchun granule Acute toxicity Genotoxicity MNOAEL Edible safety |
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