A phase I,dose escalation trial of ZD0473, a novel platinum analogue,in combination with gemcitabine |
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Authors: | Email author" target="_blank">Keith?T?FlahertyEmail author James?P?Stevenson Maryann?Redlinger Kenneth?M?Algazy Bruce?Giantonio Peter?J?O’Dwyer |
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Institution: | (1) Abramson Cancer Center of the University of Pennsylvania, Philadelphia, PA, USA;(2) Abramson Cancer Center of the University of Pennsylvania, Medical Arts Building, Suite 103, 39th & Market Streets, Philadelphia, PA 19104, USA |
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Abstract: | Purpose To develop a combination regimen for clinical testing, we performed a dose escalation study of ZD0473 in combination with gemcitabine. ZD0473 is a novel platinum analogue with an aliphatic cyclic carrier ligand. In vitro and in vivo studies suggest that it possesses a different spectrum of antitumor activity from cisplatin and carboplatin. In single-agent studies of ZD0473, myelosuppression was the predominant toxicity and responses were observed.Methods In this combination phase I trial, 36 patients with advanced cancer were accrued to four dose levels, with doses of ZD0473 and gemcitabine ranging from 60 to 120 mg/m2 and 600 to 750 mg/m2, respectively. ZD0473 was administered on day 1 and gemcitabine was given on days 1 and 8 of a 21-day cycle.Results Hematologic toxicity was dose-limiting. Grade 3 and 4 thrombocytopenia and neutropenia occurred during 60% and 41% of all cycles. Nonhematologic toxicities were mild and reversible. Two partial responses and 19 patients with stable disease were observed.Conclusions The recommended phase II doses are 90 mg/m2 of ZD0473 and 750 mg/m2 of gemcitabine for lightly pretreated patients and 600 mg/m2 for heavily pretreated patients. The combination of ZD0473 and gemcitabine is associated with dose-dependent thrombocytopenia and neutropenia as well as having promising clinical activity. |
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Keywords: | ZD0473 Platinum analogue Gemcitabine Phase I trial |
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